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Publications

2016

Goktuna, S.I., Shostak, K., Chau, T.L., Heukamp, L.C., Hennuy, B., Duong, H.Q., Ladang, A., Close, P., Klevernic, I., Olivier, F., et al. (2016). The Prosurvival IKK-Related Kinase IKKepsilon Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine. Cancer Res 76, 2587-2599. Article.

2015

Chau, T.L., Goktuna, S.I., Rammal, A., Casanova, T., Duong, H.Q., Gatot, J.S., Close, P., Dejardin, E., Desmecht, D., Shostak, K., et al. (2015). A role for APPL1 in TLR3/4-dependent TBK1 and IKKepsilon activation in macrophages. J Immunol 194, 3970-3983. Article.

Ladang, A., Rapino, F., Heukamp, L.C., Tharun, L., Shostak, K., Hermand, D., Delaunay, S., Klevernic, I., Jiang, Z., Jacques, N., Jamart, D., Migeot, V., Florin, A., Goktuna, S.I., et al. (2015). Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. J Exp Med 212, 2057-2075. Article.

2014

Goktuna, S.I., Canli, O., Bollrath, J., Fingerle, A.A., Horst, D., Diamanti, M.A., Pallangyo, C., Bennecke, M., Nebelsiek, T., Mankan, A.K., et al. (2014). IKKalpha promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells. Cell Rep 7, 1914-1925. Article.

Shostak, K., Patrascu, F., Goktuna, S.I., Close, P., Borgs, L., Nguyen, L., Olivier, F., Rammal, A., Brinkhaus, H., Bentires-Alj, M., et al. (2014a). MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation. Cell Death Differ 21, 811-824. Article.

Shostak, K., Zhang, X., Hubert, P., Goktuna, S.I., Jiang, Z., Klevernic, I., Hildebrand, J., Roncarati, P., Hennuy, B., Ladang, A., et al. (2014b). NF-kappaB-induced KIAA1199 promotes survival through EGFR signalling. Nat Commun 5, 5232. Article.

2013

Schwitalla, S., Fingerle, A.A., Cammareri, P., Nebelsiek, T., Goktuna, S.I., Ziegler, P.K., Canli, O., Heijmans, J., Huels, D.J., Moreaux, G., et al. (2013). Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152, 25-38. Article.

Stellzig, J., Chariot, A., Shostak, K., Goktuna, S.I., Renner, F., Acker, T., Pagenstecher, A., and Schmitz, M.L. (2013). Deregulated expression of TANK in glioblastomas triggers pro-tumorigenic ERK1/2 and AKT signaling pathways. Oncogenesis 2, e79. Article.

2007

Greten, F.R., Arkan, M.C., Bollrath, J., Hsu, L.C., Goode, J., Miething, C., Goktuna, S.I., Neuenhahn, M., Fierer, J., Paxian, S., et al. (2007). NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130, 918-931. Article.