Research Articles:
Targeting IRE1 with small molecules counteracts progression of atherosclerosis
Ozlem Tufanli,Pelin Telkoparan Akillilar,Diego Acosta-Alvear, Begum Kocaturk,Umut Inci Onat, Syed Muhammad Hamid, Ismail Çimen, Peter Walter, Christian Weber,and Ebru Erbay
PNAS 28 December 2016
114(8):E1395-E1404
DOI: 10.1073/pnas1621188114
Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation
Ismail Çimen, Begüm Kocatürk, Seda Koyuncu, Özlem Tufanlı, Umut I. Onat, Asli D. Yıldırım, Onur Apaydın, Şeyma Demirsoy, Zaliha G. Aykut, Uyen T. Nguyen, Steven M. Watkins, Gökhan S. Hotamışlıgil, and Ebru Erbay
Science Translational Medicine 28 Sep 2016:
Vol. 8, Issue 358, pp. 358ra126
DOI: 10.1126/scitranslmed.aaf9087
Vol. 8, Issue 358, pp. 358ra126
DOI: 10.1126/scitranslmed.aaf9087
Identification of differentially expressed microRNAs during lipotoxic endoplasmic reticulum stress in RAW264.7 macrophages / RAW264.7 makrofajlarında lipotoksik endoplazmik retikulum stres sürecinde ifadesi değişen mikroRNAların tanımlanması
Mısra Nadir1 / Özlem Tufanlı2 / Ebru Erbay2 / Arzu Atalay1
Babaev V.R., Runner R.P., Fan D, Ding L, Zhang Y, Tao H, Erbay E, Görgün
C.Z., Fazio S., Hotamisligil G.S., Linton M.F. “Macrophage Mal1 deficiency
suppresses atherosclerosis in low-density lipoprotein receptor-null mice
by activating peroxisome proliferator-activated receptor-γ-regulated
genes”. Arterioscler Thromb Vasc Biol. v31(6) p1283, 2011
C.Z., Fazio S., Hotamisligil G.S., Linton M.F. “Macrophage Mal1 deficiency
suppresses atherosclerosis in low-density lipoprotein receptor-null mice
by activating peroxisome proliferator-activated receptor-γ-regulated
genes”. Arterioscler Thromb Vasc Biol. v31(6) p1283, 2011
Erbay E., Babev, V.R., Mayers, J.R., Makowski, L, Tape, K.N., Fazio, S.,
Wiest, M.M., Watkins, S.M., Linton, M.F., and Hotamisligil G.S. “Reducing
ER stress through a macrophage lipid chaperone alleviates atherosclerosis”
Nature Medicine, v15(12) p1383, 2009
Wiest, M.M., Watkins, S.M., Linton, M.F., and Hotamisligil G.S. “Reducing
ER stress through a macrophage lipid chaperone alleviates atherosclerosis”
Nature Medicine, v15(12) p1383, 2009
Tuncman, G., Erbay, E., Hom, X., De Vivo, I., Campos, H., Rimm, E., and
Hotamisligil, G.S., “A Functional Genetic Variant at the Fatty Acid
Binding Protein, aP2, Locus Reduces the Risk for Hypertriglyceridemia,
Type 2 Diabetes and Cardiovascular Disease” PNAS v103(18) p6970, 2005
Binding Protein, aP2, Locus Reduces the Risk for Hypertriglyceridemia,
Type 2 Diabetes and Cardiovascular Disease” PNAS v103(18) p6970, 2005
Park I.H., Erbay E., Nuzzi P. and Chen,J. "Regulation of skeletal muscle
maturation and hypertrophy by mTOR” ExpCellBio v309 (1) p211, 2005
maturation and hypertrophy by mTOR” ExpCellBio v309 (1) p211, 2005
Erbay E., Park I.H., Nuzzi P., Schoenherr C.J., and Chen J. "IGF-II
transcription in skeletal myogenesis is controlled by mTOR and nutrients"
J.Cell Biol. v163(5) p931, 2003
transcription in skeletal myogenesis is controlled by mTOR and nutrients"
J.Cell Biol. v163(5) p931, 2003
Erbay E., and Chen J. "mTOR regulates C2C12 myogenesis via a
kinase-independent mechanism" J.Biol.Chem (Accelerated publication) v276,
p36079, 2002
kinase-independent mechanism" J.Biol.Chem (Accelerated publication) v276,
p36079, 2002
Reviews:
Erbay E. “Fine-tuning inflammasome activity with a small molecule or a ketogenic diet” Sci Transl Med 279ec47, 2015 Erbay E. “Therapeutic treasure hunt in the myeloid secretome” Sci Transl Med 272ec15, 2015
Erbay E. “ER-Mitochondrial communication gets stressful” Sci Transl Med 267ec213, 2014
Erbay E. “BETing on the therapeutic potential of superenhancers” Sci Transl Med 260ec184, 2014
Erbay E. “Stress inflames atherosclerosis” Sci Transl Med 248ec134, 2014
Erbay E. “Sumo wrestling atherosclerosis” Sci Transl Med 254ec158, 2014
Erbay E. “Bacteria-driven atherosclerosis” Sci Transl Med 236ec83, 2014
Erbay E. “Turbulent times for atherosclerosis epigenome” Sci Transl Med 242ec108, 2014
Erbay E. “ Micro(RNA)managing endothelial regeneration” Sci Transl Med 230ec57, 2014
Hotamisligil, G.S and Erbay, E. Nutrient sensing and inflammation in metabolic diseases Nature Reviews Immunology 8: 923, 2008. (doi: 10.1038/nri2449)
Erbay E., Cao H, Hotamisligil G.S., “The role of lipid chaperones in metabolic disease” Current Atherosclerosis Reports 9: 222, 2007. (PMID: 18241617)
Book Chapters:
Erbay E., Kim J., and Chen J. “Nutrient-dependent regulation of mTOR”.
Book chapter for “Nutrients and Cell Signaling” by Marcel Dekker Inc., New
York, 2005
Book chapter for “Nutrients and Cell Signaling” by Marcel Dekker Inc., New
York, 2005
Erbay, E. and Hotamisligil, G.S. Inflammatory causes of obesity and
metabolic diseases. Book chapter for “The Handbook of Obesity - 3rd
edition” by Taylor and Francis., New York, in press
metabolic diseases. Book chapter for “The Handbook of Obesity - 3rd
edition” by Taylor and Francis., New York, in press