Recent Publications

Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet’s disease severity Kahraman T, Gucluler G, Simsek I, Yagci FC, Yildirim M, Ozen C, Dinc A, Gursel M, Ikromzoda L, Sutlu T, Gay S, Gursel I. Journal of Extracellular Vesicles, 6:1, 1284449, 2017
Effect of egg storage duration and brooding temperatures on chick growth, intestine morphology and nutrient transporters. Yalcin S, Gursel I, Bilgen G, Horuluoglu BH, Gucluer G, Izzetoglu GTAnimal. Feb 21:1-7, 2017
Impaired toll like receptor-7 and 9 induced immune activation in chronic spinal cord injured patients contributes to immune dysfunction. Gucluler G, Adiguzel E, Gungor B, Kahraman T, Gursel M, Yilmaz B, Gursel I, PLoS One. Feb 7;12(2): e0171003, 2017
Encapsulation of two different TLR ligands into liposomes confer protective immunity and prevent tumor development. Bayyurt B, Tincer G, Almacioglu K, Alpdundar E, Gursel M, Gursel I. Control Release, 247:134-144, 2017
Involvement of Sting-Activating Cyclic Di-Nucleotides on T-Cell Differentiation and Function: An Unresolved Issue. Yildiz B, Gursel I, Turkish J. Immunol, 4 (3), 47-51, 2016
Development of CpG ODN Based Vaccine Adjuvant Formulations Gursel M, Gursel I, Methods Mol Biol.;1404:289-98, 2016
Evidence-Based Clinical Use of Nano-sized Extracellular Vesicles in Nanomedicine. Stefano F, Borras F, Buzás E, Camussi G, Cappello F, Carvalho J, Cordeiro-da-Silva A, Del Portillo H, El-Andaloussi S, Trcek TF, Furlan R, Hendrix A, Gursel I, Kralj-Iglic V, Kaeffer B, Kosanovic M, Lekka M, Lipps G, Logozzi M, Marcilla A, Marei S, Llorente AM, Nazarenko I, O'Driscoll L, Oliveira C, Pocsfalvi G, Rajendran L, Raposo G, Rohde E, Siljander P, Van Niel G, Vasconcelos HM, Yliperttula ML, Mó MY, Zarovni N, Zavec AB, Giebel B. ACS Nano,10(4):3886-99, 2016
Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides. Bayik D, Gursel I, Klinman DM. Pharmacol Res. 105:216-25, 2016
Intestinal Microbiota in Patients with Spinal Cord Injury. Gungor B, Adıguzel E, Yilmaz B, Gursel M, Gursel I. PLoS One, 11(1): e0145878, 2016
The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelial-mesenchymal transition in breast cancer. Raza U, Saatci Ö, Uhlmann S, Ansari SA, Eyüpoğlu E, Yurdusev E, Mutlu M, Ersan PG, Altundağ MK, Zhang JD, Doğan HT, Güler G, Şahin Ö. Oncotarget. 2016 Jul 8.
miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer. Mutlu M, Saatci Ö, Ansari SA, Yurdusev E, Shehwana H, Konu Ö, Raza U, Şahin Ö. Sci Rep. 2016 Sep 7;6:32541.
Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer. Tunçer S, Tunçay Çağatay S, Keşküş AG, Çolakoğlu M, Konu Ö, Banerjee S. Cell Prolif. 2016 Aug;49(4):448-59.
Functionally conserved effects of rapamycin exposure on zebrafish. Sucularli C, Shehwana H, Kuscu C, Dungul DC, Ozdag H, Konu O. Mol Med Rep. 2016 May;13(5):4421-30.
The pro-survival IKK-related kinase IKKepsilon integrates LPS and IL-17A signaling cascades to promote Wnt-dependent tumor development in the intestine.. Goktuna SI, Shostak K, Chau TL, Heukamp LC, Hennuy B, Duong HQ, Ladang A, Close P, Klevernic I, Olivier F, Florin A, Ehx G, Baron F, Vandereyken M, Rahmouni S, Vereecke L, Van Loo G, Büttner R, Greten F, Chariot A. Cancer Res. 2016 Mar 15.

Purinergic signalling of the immune system. Cekic C, Linden J. Nat Rev Immunol. 2016 Feb 29;16(3):177-92

Patrolling monocytes control tumor metastasis to the lung. Hanna RN, Cekic C, Sag D, Tacke R, Thomas GD, Nowyhed H, Herrley E, Rasquinha N, McArdle S, Wu R, Peluso E, Metzger D, Ichinose H, Shaked I, Chodaczek G, Biswas SK, Hedrick CC. Science. 2015 Nov 20;350(6263):985-90

Transgelin gene is frequently downregulated by promoter DNA hypermethylation in breast cancer. Sayar N, Karahan G, Konu O, Bozkurt B, Bozdogan O, Yulug IG. Clin Epigenetics. 2015 Sep 28;7:104.
Relative expression of rRNA transcripts and 45S rDNA promoter methylation status are dysregulated in tumors in comparison with matched-normal tissues in breast cancer. Karahan G, Sayar N, Gozum G, Bozkurt B, Konu O, Yulug IG. Oncol Rep. 2015 Jun;33(6):3131-45.
Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition. Alotaibi H, Basilicata MF, Shehwana H, Kosowan T, Schreck I, Braeutigam C, Konu O, Brabletz T, Stemmler MP. Biochim Biophys Acta. 2015 Jun;1849(6):731-42.
Differential expression patterns of metastasis suppressor proteins in basal cell carcinoma. Bozdogan O, Yulug IG, Vargel I, Cavusoglu T, Karabulut AA, Karahan G, Sayar N. Int J Dermatol. 2015 Aug;54(8):905-15.

Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG. Yildiz S, Alpdundar E, Gungor B, Kahraman T, Bayyurt B, Gursel I, Gursel M. Eur J Immunol. 2015 Apr;45(4):1170-9.
Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstruction. Bonora E, Bianco F, Cordeddu L, Bamshad M, Francescatto L, Dowless D, Stanghellini V, Cogliandro RF, Lindberg G, Mungan Z, Cefle K, Ozcelik T, Palanduz S, Ozturk S, Gedikbasi A, Gori A, Pippucci T, Graziano C, Volta U, Caio G, Barbara G, D'Amato M, Seri M, Katsanis N, Romeo G, De Giorgio R. Gastroenterology. 2015 Apr;148(4):771-782.e11.

The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Sag D, Cekic C, Wu R, Linden J, Hedrick CC. Nat Commun. 2015 Feb 27;6:6354.
Colon Cancer Associated Transcript-1 (CCAT1) Expression in Adenocarcinoma of the Stomach. Mizrahi I, Mazeh H, Grinbaum R, Beglaibter N, Wilschanski M, Pavlov V, Adileh M, Stojadinovic A, Avital I, Gure AO, Halle D, Nissan A. J Cancer. 2015 Jan 1;6(2):105-10.

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease. Unal Gulsuner H, Gulsuner S, Mercan FN, Onat OE, Walsh T, Shahin H, Lee MK, Dogu O, Kansu T, Topaloglu H, Elibol B, Akbostanci C, King MC, Ozcelik T, Tekinay AB. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18285-90.

Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition. Yilmaz-Ozcan S, Sade A, Kucukkaraduman B, Kaygusuz Y, Senses KM, Banerjee S, Gure AO. PLoS One. 2014 Sep 17;9(9):e107905.
Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings. Gungor B, Yagci FC, Gursel I, Gursel M. Oncoimmunology. 2014 Jul 3;3(7):e950166.
Autologous anti-SOX2 antibody responses reflect intensity but not frequency of antigen expression in small cell lung cancer. Atakan S, Bayiz H, Sak S, Poyraz A, Vural B, Yildirim AS, Demirag F, Gure AO. BMC Clin Pathol. 2014 Jun 7;14:24

Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors. Sahin O, Wang Q, Brady SW, Ellis K, Wang H, Chang CC, Zhang Q, Priya P, Zhu R, Wong ST, Landis MD, Muller WJ, Esteva FJ, Chang J, Yu D. Cell Res. 2014 May;24(5):542-59.
Identification of novel reference genes based on MeSH categories. Ersahin T, Carkacioglu L, Can T, Konu O, Atalay V, Cetin-Atalay R. PLoS One. 2014 Mar 28;9(3):e93341.
Population distribution and ancestry of the cancer protective MDM2 SNP285 (s117039649). Knappskog S, Gansmo LB, Dibirova K, Metspalu A, Cybulski C, Peterlongo P, Aaltonen L, Vatten L, Romundstad P, Hveem K, Devilee P, Evans GD, Lin D, Van Camp G, Manolopoulos VG, Osorio A, Milani L, Ozcelik T, Zalloua P, Mouzaya F, Bliznetz E, Balanovska E, Pocheshkova E, Kučinskas V, Atramentova L, Nymadawa P, Titov K, Lavryashina M, Yusupov Y, Bogdanova N, Koshel S, Zamora J, Wedge DC, Charlesworth D, Dörk T, Balanovsky O, Lønning PE. Oncotarget. 2014 Sep 30;5(18):8223-34.

CpG ODN nanorings induce IFNα from plasmacytoid dendritic cells and demonstrate potent vaccine adjuvant activity. Gungor B, Yagci FC, Tincer G, Bayyurt B, Alpdundar E, Yildiz S, Ozcan M, Gursel I*, Gursel M*. Sci Transl Med. 2014 May 7;6(235):235ra61.
Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair. Dal GM, Ergüner B, Sağıroğlu MS, Yüksel B, Onat OE, Alkan C, Özçelik T. J Med Genet. 2014 Jul;51(7):455-9.

Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings. Gungor B, Yagci FC, Gursel I, Gursel M. Oncoimmunology. 2014 Jul 3;3(7)

Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment. Cekic C, Day YJ, Sag D, Linden J Cancer Res. 2014 Dec 15;74(24):7250-9.

Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment. Cekic C, Linden J. Cancer Res. 2014 Dec 15;74(24):7239-49.

Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion. Onat OE, Gulsuner S, Bilguvar K, Nazli Basak A, Topaloglu H, Tan M, Tan U, Gunel M, Ozcelik T. Eur J Hum Genet. 2013 Mar;21(3):281-5.