CHEMTalks Weekly Seminar Series hosts Asst. Prof. Fabienne Dumoulin on April 11th, at 12:40. Her talk is titled “Phthalocyanines are ideal yet perfectible photosensitizers for PDT”. All department members and students are cordially invited.
Abstract : The maximum absorption wavelength of phthalocyanines is centered around 680 nm but can be tailoted by playing with the substitutiın and metalation pattern. This makes them attractive photosensitisers for photodynamic therapy, as NIR absorption allows a deeper tissue penetration and excitation in the therapeutic window.
Besides, the chemical functionalization possibilities of phthalocyanines are rather versatile, offering multiple conjugation opportunities. We developed rational design approaches based on a fine tuning of the desired properties together with SAR considerations and this talk will show how and why phthalocyanines are ideal yet perfectible photosensitizers for PDT.
See more in: Nanomedicine: Nanotechnology, Biology, and Medicine 2017, dx.doi.org/10.1016/j.nano.2017.02.002 / Eur. J. Med. Chem. 2016, 124, 284-298 / Photodiagn. Photodyn. Ther., 2016, 16, 12-14 / New. J. Chem 2015, 39, 3929-3935 / PlosOne, 2014, 9(5): e97894 / Dalton Trans. 2014, 43, 6897–6908 / Photochem. Photobiol. 2014, 90, 1376–1386 / Arkivoc, 2014, (i) 142-204 / Molecular Pharmaceutics 2013, 10, 3706−3716 / J. Porphyrins Phthalocyanines 2013, 17, 596-603 / J. Porphyrins Phthalocyanines 2013, 17, 980-988 / Turkish J. Chem. 2013, 37, 394-404 / Photodiagn. Photodyn. Ther. 2013, 10, 252-259 / Tetrahedron Lett. 2012, 53, 5227-5230 / Nanoscale 2012, 4, 2034-2045 / Org. Biomol. Chem. 2012, 10, 1154-1157 / Tetrahedron Lett. 2011, 52, 4395–4397 / J. Porphyrins Phthalocyanines 2011, 15, 481–504 / Dalton Trans. 2011, 40, 4067-4079 / Tetrahedron Lett. 2010, 51, 6615-6618 / Coord. Chem. Rev. 2010, 254, 2792-2847 / Tetrahedron 2010, 66, 3248-3258 / New. J. Chem. 2010, 34, 1153–1162 / Langmuir 2010, 26(8), 5726-5733 / Photochem. Photobiol. Sci. 2009, 8, 312–318 / J. Porphyrins Phthalocyanines 2008, 12, 1090-1095 /
About Fabienne Dumoulin : Yrd. Doç. Dr. Fabienne Dumoulin graduated in Biochemistry and completed her Master and PhD theses in Organic Chemistry at the University Claude Bernard Lyon 1, France, where she earned in 2002 a doctoral thesis on the self-assemblies of neoglycolipids. After a post-doc in Pisa, Italy, she joined the Chemistry Department of Gebze Technical University in 2005, where she got interested in the chemistry, properties and applications of tetrapyrrolic derivatives, mainly phthalocyanines.
Her two major research topics are the development of new synthetic methods towards highly asymmetrically substituted phthalocyanines, and the design and synthesis of photosensitisers for photodynamic therapy, for which she established several international collaborations with teams in UK, Poland, Malaysia, France or Austria, among others. This led to the publication of 60+ research articles, three book chapters and the completion of 4 PhD and 5 Master theses.
She has been awarded the GEBİP – Young Scientist Outstanding Achievement Award from the Turkish Academy of Sciences, the BAGEP – Young Young Scientists Award from the Bilim Akademisi and the Young investigator award from the Mustafa N Parlar Foundation of METU. She chaired the GTÜ-photodynamic days and is currently officer of the executive committee of the European Society for Photobiology, associate editor for the RSC Advances journal, and member of the Turkish mirror group of the European Technology Platform on Nanomedicine.